Principal Research Interest:

Emphasis Group:

Human Nutrition

Principal Research Interest:

Dr. Folts' primary research interest is in mechanisms that increase or decrease in vivo platelet activity and platelet-mediated coronary thrombosis. In the early 1970s, he developed an experimental model to study in vivo thrombus formation in stenosed arteries with endothelial and medial damage. In 1974, he first demonstrated in vivo that aspirin can significantly reduce the incidence of coronary t hrombosis. Currently, he is studying the antiplatelet/antioxidant properties of polyphenolic compounds found in red wine, dark beer, fruit juices, and tea.

These compounds appear to be better platelet inhibitors than aspirin. He has published over 125 papers and chapters in books, primarily on topics related to platelet interactions with damaged arterial walls, and food sources that are thought to be protective against the development of atherosclerosis. His current focus is on functional foods containing polyphenolic compounds called flavonoids, like red wine, purple grape juice, and onions, which have antiplatelet/antioxidant properties, and improve the function of the endothelium allowing for better arterial dilation.

These substances are studied in animal models and human volunteers, with risk factors and with proven coronary artery disease.

Representative Publications:

Shanmuganayagam D, Warner TF, Krueger CG, Reed JD, Folts JD. Concord grape juice attenuates platelet aggregation, serum cholesterol and development of atheroma in hypercholesterolemic rabbits. Atherosclerosis. 2007 Jan;190(1):135-42.

Nork TM, Kim CB, Shanmuganayagam D, Van Lysel MS, Ver Hoeve JN, Folts JD. Measurement of regional choroidal blood flow in rabbits and monkeys using fluorescent microspheres. Arch Ophthalmol. 2006 Jun;124(6):860-8.

Maalej N, Osman HE, Shanmuganayagam D, Shebuski RJ, Folts JD. Antithrombotic properties of the thromboxane A2/prostaglandin H2 receptor antagonist S18886 on prevention of platelet-dependent cyclic flow reductions in dogs. J Cardiovasc Pharmacol. 2005 May;45(5):389-95.

Mann LB, Folts JD. Effects of ethanol and other constituents of alcoholic beverages on coronary heart disease: a review. Pathophysiology. 2004 Apr;10(2):105-12.

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